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Confusion and Substitute glitch
The Confusion and Substitute glitch is a natural glitch in Pokémon Red, Blue, and Yellow. If a Pokémon under a Substitute hurts itself due to Confusion, damage will be dealt to the other Pokémon's Substitute, even if it doesn't have one.
This may cause the game to display a message that the other Pokémon's Substitute broke, drop its sprite and then redraw it.